An experienced researcher specializing in atrial fibrillation, Dr. Sanjiv M. Narayan, professor of medicine at Stanford University, is responsible for developing innovative assessment tools for diagnosing heart arrhythmia conditions. Dr. Sanjiv M. Narayan’s research recently focused on the mechanisms of and relationship between localized ablation and persistent atrial fibrillation termination.
As part of a clinical trial, researchers hypothesized that local ablation sites where AF persistently terminates have certain indicators that can be analyzed through activation mapping techniques. To test this theory, they closely studied activation patterns that occurred solely in instances of AF termination via ablation.
After examining the results, the research team found patterns of either rotational or focal activity when mapping termination sites. Computer simulations also revealed rotational activation sequences, but the sequences were found to have increased sensitivity to activation timing, especially in areas where slow conduction was a factor. Based on these observations, the researchers stated that many currently used tools to map AF may not detect important regions, including sites of termination, and further studies should compare mapping approaches to guide ablation.